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Later on, it has been shown that more than 200 variants exist in the coding region of TMAO producing enzyme, with different outcomes on the cardiovascular risk (Phillips and Shephard, 2020)

[14] [15] The synthetic GLP-1 receptor agonists mimic this endogenous hormone but are structurally modified to resist rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), resulting in prolonged therapeutic activity

DOI: 10.1016/j.mito.2024.101877 Enhanced Mitochondrial Mrs2-Mg2+ Signaling Drives Mitochondrial Dysfunction in Pulmonary Arterial Hypertension Rats by Ruo-Nan Chen, Xue-Qin Weng, Yan Yan, Qin-Ye Chen, Yi-Chen Lin, Lan Liu, Xiao-Ling Zhuang, Long-Xin Gui, James S.K

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